Fig 1: Inducible nitric oxide synthase (iNOS) protein level (panel (A)) and NOx production (panel (B)) in human plasma at the end of a 5-week workout program consisting of 20 min low-intensity exercise session every other day. Box and Whisker plots indicate the median, 1st quartile, 3d quartile, interquartile range, minimum, and maximum in comparison to the baseline (time 0), which was set at 100%. * p < 0.05, ** p < 0.01 vs. the baseline before oxygen exposure (time 0), for the Wilcoxon test.
Fig 2: Acute and chronic hypobaric hypoxia-induced unbalance of oxidative stress and changes in nitric oxide metabolism: (a) thiobarbituric acid-reactive substances (TBARS) (µM); (b) protein carbonyls (PC) (nmol·mg-1 protein); (c) 8-hydroxy-2-deoxyguanosine (8-OH-dG) (ng·mL-1); (d) nitric oxide metabolites (NOx) (µM); (e) inducible nitric oxide synthase (iNOS) (I.U.), time course of concentration data. Data are shown as mean ± SD. Significant differences compared to T0 (baseline): p < 0.05 (* symbol).
Fig 3: Histogram plot (% ± SD) of (A) Reactive Oxygen Species (ROS), (B) Total Antioxidant Capacity (TAC), (C) 8-isoprostane (8-iso PGF-2a), (D) NO metabolites (NOx), (E) iNOS, (F) IL-6, (G) IL-10, and (H) TNF-a, obtained from plasma samples collected. The control group (Ctr) is reported in grey; white and black bars identify T1 and T2, respectively. Significant differences intra-group: * p < 0.05; ** p < 0.01; *** p < 0.001. Significant difference between groups: # p < 0.05.
Fig 4: Panels show the histogram plot (mean ± SD) of (A) NO metabolites (NOx) (ELISA), (B) nitrite (NO2) (ELISA), (C) nitrotyrosine (3-NT) (ELISA) and (D) inducible nitric oxide synthase (iNOS) (ELISA). * p < 0.05, ** p < 0.01 significant difference.
Fig 5: Bar charts (mean ± SD) of A NO metabolites (NOx), B nitrite (NO2), and C inducible nitric oxide synthase (iNOS), collected at T0 and T4 *p < 0.05, significantly different
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